Protein Modification Reagents
![eMolecules Broadpharm / TCO-PEG2-DBCO / 25mg / 672542384 / BP-25757 / / / [null] / 587.717 / C34H41N3O6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502499597.JPG-250.jpg)
eMolecules Broadpharm / TCO-PEG2-DBCO / 25mg / 672542384 / BP-25757 / / / [null] / 587.717 / C34H41N3O6
Broadpharm / TCO-PEG2-DBCO / 25mg / 672542384 / BP-25757 / / / [null] / 587.717 / C34H41N3O6
Medchemexpress LLC 4-imidazolidinehexanamide, n-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-5-methyl-2-oxo-, (4R,5S)- | 2306109-91-9 | 99.2% | C20H40N4O6 | 10MG
Amine-PEG4-Desthiobiotin is a PEG-based linker bearing a primary amine and a desthiobiotin moiety used to assemble proteolysis-targeting chimeras (PROTACs), affinity probes, and bioconjugates. The reagent supplies a hydrophilic spacer and a reactive handle to link target-binding ligands to recruiting ligands, supporting modular synthesis and downstream affinity-based workflows.
- Provides a primary amine for straightforward conjugation using standard amide-coupling chemistries.
- Contains a desthiobiotin moiety for reversible affinity capture with streptavidin-based systems.
- PEG4 spacer imparts hydrophilicity and flexible linkage between functional groups.
- High reported purity supports reproducible synthesis and analytical characterization.
- Stable when stored frozen and in solution under recommended conditions.
Medchemexpress LLC Dbco-PEG4-VA-PBD | 2241644-09-5 | 99.7% | 1430.60 | C80H87N9O16 | 1 MG
DBCO-PEG4-VA-PBD is a drug-linker conjugate intended for antibody-drug conjugate (ADC) conjugation workflows. The molecule features a DBCO reactive group for strain-promoted alkyne-azide cycloaddition (SPAAC), a PEG4 spacer, a valine-alanine protease-cleavable linker, and a pyrrolobenzodiazepine (PBD) cytotoxic payload. Supplied as a solid for research use.
- Contains DBCO group for SPAAC click chemistry
- Includes PEG4 spacer for improved solubility
- Valine-alanine cleavable linker enables intracellular payload release
- PBD payload for potent cytotoxic activity
- Supplied as 1 mg solid; purity reported ~99.7%
- Store at -80°C under nitrogen; shipped on dry ice
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG8-CH2COOH | 10 g | CAS 868594-52-9 | MDL MFCD27635163
Fmoc-NH-PEG8-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 10 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 868594-52-9
- MDL: MFCD27635163
- InChIKey: JRLUSGRARXJCNA-UHFFFAOYSA-N
- Molecular Weight: 649.734
- Molecular Formula: C33H47NO12
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azatriacontan-30-oic acid
- SMILES: O=C(COCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Aat Bioquest DBCO-Cy3
This azadibenzocyclooctyne-cyanine dye derivative is a versatile labeling reagent for detection of azide containing molecules or compounds. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions.
Avanti Polar Lipids DSPE-PEG(2000)MALEIMIDE 50MG
DSPE-PEG(2000)Maleimide, Molecular Weight: 2941.64, Molecular Formula: C 139 H 271 N4O 57 P, Powder form, White Color, Not Flammable, 50mg
Medchemexpress LLC S-acetyl-dPEG8-NHS ester | 1070798-99-0 | MFCD11041104 | >97.0% | 597.7 g/mol | C25H43NO13S | 50 MG
dPEG8-SATA (S-acetyl-dPEG8-NHS ester) is a heterobifunctional polyethylene glycol reagent used to introduce a protected thiol group onto biomolecules via NHS-ester chemistry. The hydrophilic dPEG8 spacer provides defined spacing and aqueous solubility, while the SATA protecting group allows controlled deprotection to liberate a free thiol for downstream conjugation and crosslinking applications.
- Provides a protected thiol for controlled thiolation.
- Reacts via NHS-ester chemistry for efficient amine labeling.
- Hydrophilic spacer improves solubility in aqueous media.
- Defined spacer length reduces steric hindrance in conjugates.
- High purity suitable for bioconjugation workflows.
- Available in multiple pack sizes for laboratory use.
Medchemexpress LLC Dspe-peg2-mal | 1915739-87-5 | 99.9% | C55H100N3O14P | 10MG
DSPE-PEG2-mal is a PEG-based linker comprising a distearoylphosphatidylethanolamine (DSPE) lipid connected via a short PEG2 spacer to a maleimide functional group. It is intended for thiol-selective conjugation and linker installation in PROTACs, lipidated probes, and general bioconjugation research.
- Contains a maleimide terminus for selective reaction with thiols.
- Features a short PEG2 spacer to enhance solubility and flexibility.
- Includes a DSPE lipid moiety for membrane anchoring and lipidation.
- High reported purity supports reproducible synthesis and analysis.
- Solid, white to off-white form for ease of handling and storage.
- Available in multiple small-scale pack sizes suitable for research use.
eMolecules N,N-diethanol amine-PEG4-tert-butyl ester | 2279944-66-8 | | 1g
Broadpharm | N,N-diethanol amine-PEG4-tert-butyl ester | 1g | 550804567 | BP-24231 | | 2279944-66-8 | | 409.520 | C19H39NO8
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Broadpharm Methyltetrazine-propylamine HCl salt | 1802978-47-7 | MFCD28334554 | 100mg
Methyltetrazine-propylamine HCl salt | Putity: 95% | MW: 245.3 | 1802978-47-7 | MFCD28334554 | 100mg
![Medchemexpress LLC 4,7,10,13-tetraoxahexadecanediamide, N1,N16-bis[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl] | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204012.png-250.jpg)
Medchemexpress LLC 4,7,10,13-tetraoxahexadecanediamide, N1,N16-bis[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl] | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 25 MG
DBCO-PEG4-DBCO is a PEG-based bifunctional dibenzocyclooctyne (DBCO) linker that enables strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free click chemistry. It contains two DBCO groups connected by a PEG4 spacer, is supplied as a white-to-yellow solid, and is used as a cleavable linker in ADC and PROTAC synthesis.
- enables copper-free SPAAC (strain-promoted alkyne-azide cycloaddition)
- contains two DBCO reactive groups connected by a PEG4 spacer
- high purity: 97.4% (HPLC)
- molecular weight: 810.93 g/mol
- supplied as a white-to-yellow solid with recommended sealed, moisture-free storage
Medchemexpress LLC Dspe-peg-fitc | 600 g/mol (average) | 5 MG
DSPE-PEG-FITC (MW 600) is a fluorescein-labeled PEGylated phospholipid used as a fluorescent lipid probe for preparation of liposomes and nanoparticles, surface labeling, and tracking in research applications. The material is supplied as a light yellow to yellow solid and is intended for laboratory research; storage is recommended at 4°C protected from light, and in solvent at -80°C for up to 6 months or at -20°C for up to 1 month.
- Fluorescent labeling for liposomes and nanoparticles.
- Amphiphilic PEGylated phospholipid enabling micelle and liposome formation.
- Average molecular weight 600 for consistent labeling performance.
- Light yellow solid for convenient storage and handling.
- Stable when stored protected from light; solvent storage at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Biotinyl-NH-PEG3-C3-amido-C3-COOH | 1202761-21-4 | 99.3% | 50 MG
Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is for research use only and not sold to patients.
- Solid appearance
- White to off-white color
- Soluble in DMSO (250 mg/mL)
- Soluble in methanol (≥ 100 mg/mL)
- Molecular weight: 560.70
- Molecular formula: C25H44N4O8S
Medchemexpress LLC Dbco-conh-s-s-nhs ester | 1435934-53-4 | MFCD22380758 | 99.2% | 565.66 g/mol | C28H27N3O6S2 | 5 MG
DBCO-CONH-S-S-NHS ester is a cleavable disulfide-containing ADC linker that combines a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with an N-hydroxysuccinimide (NHS) activated ester for conjugation to amines.
- Provides a cleavable disulfide spacer for controlled payload release.
- Enables copper-free click chemistry via DBCO for bioorthogonal conjugation.
- Contains an NHS-activated ester for efficient amine coupling.
- High reported purity supports sensitive bioconjugation workflows.
- Soluble in DMSO at high concentrations for easy handling and stock preparation.
- Stable when stored protected from light and under inert atmosphere at low temperatures.